ceesdekker.net Secrets
ceesdekker.net Secrets
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Midway by way of his profession, Cees Dekker reinvented himself. Just after several years of hardcore physics, he shifted his concentrate to ‘nanobiology’ within the switch with the millennium. A term he coined himself, to be a issue of point.
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‘It absolutely was only a issue of choosing up a guide on mobile biology and starting to study. I'd originate from a earth of ultra-high vacuums, cryostats and quantum phenomena, and now I had been Doing work at space temperature with molecular biology kits.
Because 2000, Dekker has shifted the principle concentrate of his get the job done towards biophysics in which he scientific tests the properties of single biomolecules and cells using the instruments of nanotechnology. This change of area was pushed by his fascination for that remarkable working of biological molecular constructions, and by the extended-expression standpoint that many intriguing discoveries might be envisioned During this field.[5] Present lines of analysis in his biophysics team are while in the parts of:[six]
2015, discovery that condensin is really a highly adaptable protein construction; and initial detection of DNA knots applying nanopores
Immediate immobilization of native yeast iso-one cytochrome c on bare gold: quickly electron relay to redox enzymes and zeptomole protein-movie voltammetry
We form germs into types that deviate from their all-natural phenotype. Particularly, I'll clearly show our capacity to form Reside E. coli bacteria into novel styles for instance rectangles, squares, triangles and circles.
Dynamic ParB–DNA interactions initiate and manage a partition condensate for bacterial chromosome segregation
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Very awesome, but that wasn’t actually wherever my desire lay. I needed to pioneer And that i had the feeling that was not attainable, since the most appealing elementary insights experienced by now been uncovered. But my subject experienced formulated lots of exciting new tools to evaluate unique molecules. I made a decision which i planned to implement this to biology, to have a look at it from the Bodily perspective.’
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Cees Dekker is Distinguished College Professor at TU Delft. Experienced being a physicist, he pioneered nanotechnology with several discoveries on carbon nanotubes within the 1990s. Considering the fact that 2000, he moved to solitary-molecule biophysics ceesdekker.net and nanobiology. His present research concentrates on (i) nanopores for protein sequencing; (ii) chromosome construction, in particular SMC motor protein; and (iii) developing a residing artificial mobile from lifeless molecules. Dekker is definitely an elected member of the KNAW and fellow to your APS plus the IOP.
2008, initial observation of protein-coated DNA translocation through nanopores; fixed the origin with the electrophoretic power on DNA in nanopores; found a significant velocity improve of microtubules in electrical fields; identified an anomalous electro-hydrodynamic orientation of microtubules; and resolved the origin of sounds in carbon nanotubes in liquid
2013, managed shaping of Dwell bacterial cells into arbitrary shapes; and discovery of spontaneous fluctuations from the handedness of histone tetrasomes